| Project Type: | Externally Funded | ||
| Project Title: | Understanding the Physiology of Bioenergetics and Aging Trial (UPBEAT) | ||
| Principal Investigator: | Anthony Molina, PhD | ||
| Other Key Investigator (1): | Jamehl Demons, MD | ||
| Other Key Investigator (2): | Mary Lyles, MD | ||
| Other Key Investigator (3): | Dalane Kitzman, MD | ||
| Other Key Investigator (4): | |||
| Project Start Date: | 07/15/2015 | ||
| Projected End Date: | 06/30/2017 | ||
| Associated Center: | Wake Forest University | ||
| Associated Core(s): |
RC1
(Clinical Research Core)
RC3 (Integrative Biology Core) RC4 (BioImaging Resource Core) |
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| Brief Description: | This study will test the hypothesis that skeletal muscle bioenergetic decline, due to mitochondrial dysfunction, is a major contributor to exercise intolerance in patients with HFpEF. This hypothesis is based on multiple lines of evidence indicating that: 1) older HFpEF patients have reduced peak exercise arteriovenous-oxygen difference that contributes to reduced peak VO2; 2) improved peak exercise arteriovenous-oxygen difference accounts for nearly all peak VO2 improvement in HFpEF patients following endurance training; 3) skeletal muscle oxidative metabolism is reduced in HFpEF; 4) impaired skeletal muscle oxygen utilization limits exercise performance in HFpEF; and 5) HFpEF patients have fewer type-I oxidative muscle fibers. | ||
| Project Keywords: |
Physical Function Human Subjects Obesity/Weight Loss mitochondrial quality control, muscle samples, |
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| Registered By: | Abby Archer | ||
| Registered On: | 08/15/2016 | ||
| Project Status: | Active | ||
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