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Claude D. Pepper Older Americans Independence Centers (OAIC)

The goal of the OAIC program is to increase scientific knowledge that allows older adults to maintain or restore their independence. The NIA supports the OAICs to develop and enhance research and education at institutions with strong programs in aging research. This support is critical to address key research problems, technological limitations, and faculty development needs for future generations of appropriately-trained researchers. The OAICs are also known as "Pepper Centers" - so named to honor the late Senator Claude D. Pepper who championed the effort to create these centers of excellence. - Kevin P. High, MD, MS, Director

Click logo to download RFP (12/11)
R24 Concept Proposal Submission

 Research Spotlight

Functional Decline in Patients with Cirrhosis Awaiting Liver Transplantation: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study.

Lai JC, Dodge JL, Sen S, Covinsky K, Feng S.

Science Translational MedicineThis study examined the usefulness of geriatric measures of functional status such as the SPPB in assessing clinical status of patients on the liver transplant wait list. Measures such as the SPPB declined while patients were on the wait list, and the amount of decline strongly predicted wait list mortality, independent of measures of liver disease severity such as the MELD. The study supports the use of functional status measures such as the SPPB in monitoring the status of liver transplant candidates. Jennifer Lai is a UCSF OIAC career development scholar and Ken Covinsky is UCSF OAIC PI.