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Claude D. Pepper Older Americans Independence Centers (OAIC)

The goal of the OAIC program is to increase scientific knowledge that allows older adults to maintain or restore their independence. The NIA supports the OAICs to develop and enhance research and education at institutions with strong programs in aging research. This support is critical to address key research problems, technological limitations, and faculty development needs for future generations of appropriately-trained researchers. The OAICs are also known as "Pepper Centers" - so named to honor the late Senator Claude D. Pepper who championed the effort to create these centers of excellence. - Dalane W. Kitzman, MD, Director

 Research Spotlight

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction

A Randomized Clinical Trial
Dalane W. Kitzman, MD1; Peter Brubaker, PhD2; Timothy Morgan, PhD3; Mark Haykowsky, PhD4; Gregory Hundley, MD1; William E. Kraus, MD5; Joel Eggebeen, MS6; Barbara J. Nicklas, PhD7

JAMA Importance More than 80% of patients with heart failure with preserved ejection fraction (HFPEF), the most common form of heart failure among older persons, are overweight or obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major determinant of reduced quality of life (QOL).

Objective To determine whether caloric restriction (diet) or aerobic exercise training (exercise) improves exercise capacity and QOL in obese older patients with HFPEF.

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