Claude D. Pepper Older Americans Independence Centers (OAIC)The goal of the OAIC program is to increase scientific knowledge that allows older adults to maintain or restore their independence. The NIA supports the OAICs to develop and enhance research and education at institutions with strong programs in aging research. This support is critical to address key research problems, technological limitations, and faculty development needs for future generations of appropriately-trained researchers. The OAICs are also known as "Pepper Centers" - so named to honor the late Senator Claude D. Pepper who championed the effort to create these centers of excellence. Kevin P. High, MD, MS, Director Pepper National Coordinating Center
Adipose tissue density, a novel biomarker predicting mortality risk in older adults.Murphy RA, Register TC, Shively CA, Carr JJ, Ge Y, Heilbrun ME, Cummings SR, Koster A, Nevitt MC, Satterfield S, Tylvasky FA, Strotmeyer ES, Newman AB, Simonsick EM, Scherzinger A, Goodpaster BH, Launer LJ, Eiriksdottir G, Sigurdsson S, Sigurdsson G, Gudnason V, Lang TF, Kritchevsky SB, Harris TB. Background:
Knowledge of adipose composition in relation to mortality may help delineate inconsistent relationships between obesity and mortality in old age. We evaluated relationships between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) density, mortality, biomarkers, and characteristics.
VAT and SAT density were determined from computed tomography scans in persons aged 65 and older, Health ABC (n = 2,735) and AGES-Reykjavik (n = 5,131), and 24 nonhuman primates (NHPs). Associations between adipose density and mortality (4-13 years follow-up) were assessed with Cox proportional hazards models. In NHPs, adipose density was related to serum markers and tissue characteristics.
VAT and SAT density provide a unique marker of mortality risk that does not appear to be inflammation related.
NIA, one of the 27 Institutes and Centers of NIH, leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. NIA is the primary Federal agency supporting and conducting Alzheimer's disease research.