UNIVERSITY OF MICHIGAN
Claude D. Pepper Older Americans Independence Center

Raymond Yung, M.D.
Principal Investigator		   734-647-9746   ryung@umich.edu
Ryan McCleery
Program Administrator		   734-770-8571   rmccleer@med.umich.edu
     
CENTER DESCRIPTION

Funded by the NIA as the nations first Geriatric Research and Training Center in 1989, the University of Michigan (UM) Pepper Center has evolved to meet the objectives of the OAIC program with successful competing renewals as an OAIC in 1994, 1999, 2004, 2009, 2015, and 2020. Thus, our Center is completing its 31st consecutive year of operation in 2020. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults. Drawing on the large base of research currently underway in the fields of geriatrics and gerontology at UM, the UM Pepper Center fosters collaborative multidisciplinary research to integrate basic science, clinical science, and health services research relevant to the health care problems of older adults. The UM Pepper Center grant supports important research activities of the UM Geriatrics Center. Founded in 1987, the Geriatrics Center is the umbrella organization for geriatrics research, education, and patient care at the University of Michigan. The specific goals of the UM Pepper Center are:To support research that will improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status.

  • To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status.
  • To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus.
  • Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus.
  • Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center’s research focus.

Faculty from the following UM Schools and Institutes are involved: the Institute of Gerontology, School of Public Health, Institute for Social Research, Medical School, College of Engineering, School of Nursing, School of Social Work, and College of Literature, Science, and the Arts. As of 2018 there were 89 active NIA grants at the UM with over $60 million/year of total costs. The UM OAIC’s faculty participant data base includes a total of 239 current UM faculty who have 221 current external grants relevant to the UM Pepper Center’s focus totaling over $57 million/year direct costs.

CORES
Leadership and Administrative Core (LAC)
Leader 1:    Raymond Yung, MD   ryung@med.umich.edu
Leader 2:    Lona Mody, MD, MSc   lonamody@umich.edu
A well-defined and effective Leadership Administrative Core (LAC) that supports the rich activities of the OAIC is already in place. The faculty and staff in the LAC have proven leadership and administrative skills. The LAC will foster critical interactions among the OAIC Program Director, the OAIC Core Directors/Co-Directors and the leadership structure of the Institution as a whole. These linkages are fostered by the proven administrative structure, which requires meetings of the OAIC leadership on a regular and ongoing basis, and of key advisory committees: the UM Geriatrics Center’s Research Operating Committee (ROC) and the OAIC External Advisory Board (EAB). The ROC, led by two fellowship-trained geriatricians/physician scientists (Yung, Mody) with complementary expertise and research interests, provides strategic planning, coordination and oversight for all OAIC activities. The membership of the ROC includes the LAC Leader and Co-Leader, the former OAIC Director, the ten other OAIC Core Directors/Co-Directors, and Geriatrics Center administrative leaders.

Research Education Component (REC)
Leader 1:    Neil B. Alexander, MD   nalexand@med.umich.edu
Leader 2:    Lillian Min, MD, MSHS   lmin@umich.edu
Leader 3:    Carrie Karvonen-Gutierrez   ckarvone@umich.edu
The overarching goal of the UM OAIC Research Education Core (REC) is to recruit, select, support, mentor, and train junior faculty to become independent investigators in aging-related research and academic leaders in geriatrics and gerontology within their respective disciplines. A key additional objective is to train the next generation of investigators about the UM OAIC focus of how metabolic factors and inflammation interact with age-related diseases to determine key health outcomes related to mobility and functional status. The REC continues to draw from a substantial pool of UM junior faculty from a wide range of disciplines across the UM campus who are doing research relevant to the OAIC focus to participate in the proposed REC training activities.

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Lona Mody, MD   lonamody@med.umich.edu
Leader 2:    Mary Janevic, PhD, MPH   mjanevic@umich.edu
The goal of the Pilot and Exploratory Studies Core is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme: “To improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status” The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research.

Biomechanics Core (BC)
Leader 1:    James Ashton-Miller, PhD   jaam@umich.edu
Leader 2:    Neil Alexander, MD   nalexand@umich.edu
The Biomechanics Core provides an array of techniques and equipment for the precise experimental quantification of physical functioning of healthy and frail elders in order to investigate attributes of the aging phenotype. It also supplies support for theoretical investigations in the form of computer simulation models to analyze the elements of those functional abilities and to establish the major determinants of abilities to perform motor acts in an effective manner. The Core is physically based in the Biomechanics Research Laboratory(link is external) (directed by Dr. Ashton-Miller) and the Mobility Research Center(link is external) (directed by Dr. Alexander). Physical disabilities are epidemic in the elderly. Whatever the underlying pathologies, these disabilities express themselves in biomechanical terms: reduced muscular strengths and rates of developing strengths, limited ranges and speeds of motion, reduced afferent feedback, inappropriate body segment coordination patterns, difficulty with balance and fall arrests, and even impaired pelvic floor and continence system function. The Biomechanics Core will contribute to the development of academic leaders in geriatrics by helping interested faculty and their fellows to analyze a range of geriatric problems through biomechanical research techniques. Thus, it will train them through directed study involving background reviews, hypothesis generation, interdisciplinary pilot research projects, and data analysis and interpretation to examine issues adversely affecting the physical abilities of the elderly.

Core Facility for Aged Rodents (CFAR)
Leader 1:    Richard Miller, MD, PhD   millerr@umich.edu
The Core Facility for Aged Rodents, CFAR, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR serves the needs of Pepper Center investigators through four Specific Aims. CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease. CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pit1 dw mutation. Mice from these colonies will be provided to faculty members working on Pilot Studies Exploratory Core (PESC) and Research Career Development Core (RCDC) research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds. CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new four-way cross suitable for studies of late-life hearing loss.

Design, Data, and Biostatistics Core (DDBC)
Leader 1:    Andrzej Galecki, PhD, MD   agalecki@umich.edu
Leader 2:    Julie Bynum, M.D., M.Ph.   bynumju@umich.edu
The Design, Data, and Biostatistics Core (DDBC) will provide technical support and training of investigators developing or performing intervention and other geriatric research projects examining the aging phenotype and outcomes research. It will also develop new instruments, methodologies, and data archives to enable future studies. Thus the DDBC will both address techniques for appropriate design and execution of current experiments and set the foundation for future research studies. Building on our experience with the UM Pepper Center, the DDBC will address the needs of OAIC investigators, and especially junior investigators, for assistance in the design of intervention experiments, and the collection, maintenance, analysis, and interpretation of their data.

Human Subjects and Assessment (HSAC)
Leader 1:    Raymond Yung, MD   ryung@med.umich.edu
Leader 2:    Kenneth Langa, MD, PhD   klanga@umich.edu
The Human Subjects and Assessment Core (HSAC) supports activities involving human subjects at the University of Michigan Claude D. Pepper Center. It has four specific aims: HSAC will establish, maintain, and facilitate access to human subjects and related data sets. HSAC will expand, promote and facilitate access to minority human subjects through collaborative linkages with the Wayne State University Institute of Gerontology (WSU IoG). HSAC aims to provide selected efficient physical health measures, which will complement our existing collection of self-reported health, health care utilization, and psychosocial measures in subject selection. HSAC will provide training and consultation to investigators on issues related to (a) recruitment and retention of human subjects, and (b) measurement of quality of life and psychosocial factors closely linked with aging phenotype.

CAREER DEVELOPMENT
REC Scholar, Research & Grants Funded During Pepper Supported Time Years /
Publications
 
Haylie Miller
PhD / School of Kinesiology
Visuomotor Integration as a Predictor of Mobility and Fall Risk in Autistic Older Adults
  • K01 MH107774 Miller (PI) 07/15/2017–06/14/2023 (currently in NCE) Visuomotor Integration and Attention in Autism Spectrum Disorder
  • U54 MD006882 Vishwanatha (PI), Role: sub-award principal investigator, Texas Center for Health Disparities Pilot Program 11/01/2018-12/31/2020 Preliminary Assessment of Visuomotor Profiles in Hispanic Children with Autism

 2023-2024 /
47 (total)
18 (1st/Sr)
 
Aleda Leis
PhD, MS / School of Public Health
Advance uderstanding of the metabolic causes and effects of cardiometabolic disease, with and without obesity, and the implications for primary prevention and disease management in older adults
  • 75D30122C14944 (PI: Martin) 9/1/22 – 8/31/25 Centers for Disease Control and Prevention, Subaward of Vanderbilt University Medical Center Surveillance of Acutely Ill Adults with Respiratory Viruses, including SARS-CoV-2 (IVY5) The objective of this study is to continue the current Influenza and Other Viruses in the Acutely Ill (IVY) vaccine efficacy test-negative design cohort of individuals hospitalized with influenza, COVID-19, and other respiratory diseases in Southeast Michigan. Role: Co-investigator
  • 1 U01IP001193-01-00 (PI: Martin) 9/30/22 – 9/29/27 Centers for Disease Control and Prevention Michigan-Ford Initiative to Measure Vaccine Effectiveness (MFIVE): Seasonal Influenza, COVID-19 and Respiratory Virus Vaccines The objective of this study is to continue the current outpatient Michigan-Ford Influenza Vaccine Effectiveness (MFIVE) vaccine efficacy test-negative design cohort in Southeast Michigan. Role: Co-investigator
  • NIH R01 AR076994-02 (PI: Whitney) 9/23/21 – 8/31/24 National Institute of Arthritis and Musculoskeletal And Skin Diseases Addressing Knowledge Gaps by Multi-Level Research Design to Optimize Clinical Trial Development in Order to Reduce Fracture Burden for Adults with Neurodevelopmental Disabilities This project will address fundamental knowledge gaps in order to improve clinical care for skeletal fragility and to optimize clinical trial design to reduce the non-trauma fracture burden for adults with neurodevelopmental disabilities
  • AOTFHSR21Whitney (PI: Whitney) 7/1/21 – 6/30/23 American Occupational Therapy Foundation The Effect of Rehabilitation Utilization on Risk of Fragility Fracture and its Related Disease, Mortality, and Healthcare Cost Burden for Adults with Cerebral Palsy: Providing Actionable Information to Inform Rehabilitation Efforts This project will examine rehabilitation patterns and their implication in prevention of fragility fractures and associated adverse downstream clinical effects of fracture.
  • 1 U19AG063720-01A1 (MPI: Brooks (contact); Karvonen-Gutierrez; Burnett-Bowie; Derby; Hedderson; Janssen; Karlamangla; McConnell; Thurston; Waetjen) 9/30/20 – 8/31/24 National Institute on Aging (NIA), Subaward of University of Pittsburgh The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age This project will build upon the resources of the Study of Women’s Health Across the Nation (SWAN) to quantify the impact of ovarian aging, the Menopausal Transition and the midlife on successful aging.
  • NIH R01 AR068452-01 (PI: Jepsen) 8/1/18 – 7/31/23 National Institute of Arthritis and Musculoskeletal and Skin Diseases Changes in Periosteal and Endocortical Width Across the Menopausal Transition This proposal seeks to better elucidate the structural changes that underlie loss in strength during the Menopausal Transition by examining relative changes in endocortical expansion (bone loss) versus periosteal expansion (bone gain).

 2023-2024 /
58 (total)
2 (1st/Sr)
 
Past Scholars
Marco Cassone, MD, PhD, University of Michigan, Geriatrics & Palliative Medicine (2018-2020)
Jaclynn Hawkins, University of Michigan School of Social Work (2019-2020)
Xiaoling Xiang, University of Michigan School of Social Work (2019-2021)
Jiha Lee, MD, MHS, University of Michigan (2019-2021)
Matthew Pianko, M.D., Department of Internal Medicine (2021-2022)
Emily Briceno, Ph.D., Department of Physical Medicine & Rehabilitation (2021-2023)
Michael Smith, PharmD, Department of Pharmacy (2021-2022)
Joseph Endicott, M.D., Department of Pathology (2022-2023)
David Flood, M.D., M.Sc., Department of Internal Medicine (2022-2023)
Victoria Powell, M.D., Division of Geriatric and Palliative Medicine (2022-2023)

PILOT/EXPLORATORY PROJECTS (12 Pilot Projects Listed)
1. Project Title: Viral Infection Burden and Immunosenescence
  Leader: Grace Noppert, Ph.D.
  LAC Year 17 (7/1/21-6/30/22) *RAPID PILOT* Adults aged 65+ years account for 45% of hospitalizations and 53% of intensive care admissions due to COVID-19 despite comprising 17% of the U.S. population. The systemic hyperinflammatory response is a key feature observed in many severe cases of COVID-19 and may signal an underlying immunopathology related to substantial T cell stimulation. This immunopathology is likely an indication of advanced immunological age, or immunosenescence. irhe mechanisms underlying the increased risk for severe outcomes, including mortality, from COVID-19 among older adults are still being elucidated. Emerging evidence suggests that viral infections may accelerate the pace of immunosenescence. However, significant questions remain With regards to the role of viral co-infections, differential immune control of viral infections, and the ??pecific changes in the immune compartment induced by viral infections. Our long-term goal is to examine the role of viral infections in driving population-level patterns of immunosenescence. The overall obiective of the current application is to characterize the viral burden resulting from five herpesviruses by examining both seropositivity to each virus as well as antibody level with higher antibody levels reflecting worse immune control of the virus and thus a greater burden to the immune system. Using previously collected human samples from the University of Michigan's Central Biorepository, we will first characterize the viral infection burden to five human herpesesviruses and describe differences by age, race/ethnicity, and gender (Aim 1 ). We will then estimate whether viral infection burden is associated with advanced immunosenescence in the T cell compartment (Aim 2). At its conclusion, these pilot data will shed further light on the immune parameters most likely to be affected by viral infections. Ultimately, the goal of this work to provide insights into future development of interventions that can address long-term immune consequences older adults are likely to continue to face due to viral infections.
 
2. Project Title: Cross-national comparisons of disability among older adults with diabetes in 23 countries
  Leader: David Flood, M.D., M.Sc.
  PESC Year 18 (7/1/22-6/30/23) Diabetes is one of the most critical worldwide health issues for older adults. Research largely from high-income countries has shown that diabetes is associated with an increased risk of disability among older adults. However, there is limited understanding of how prevalence of disability among older adults with diabetes may be similar or different across the world. The objective of this pilot project is to assess cross-national patterns of disability among older adults with diabetes by leveraging the Global Gateway to Aging, an NIA-funded platform of harmonized data from international cohorts aligned with the U.S. Health and Retirement Study. Aim 1 will augment the Gateway to Global Aging platform by developing a harmonized measure of diabetes status in 23 countries that incorporates both questionnaire and blood-based biomarker data. Aim 2 will assess cross-national patterns of disability among older adults using the augmented Gateway to Global Aging dataset developed in Aim 1. This proposal’s focus strongly aligns with the Pepper Center’s overarching mission and will take advantage of unique expertise at the University of Michigan through interaction with Dr. Kenneth Langa (Human Subjects and Assessment Core) and Dr. Andrzej Galecki (Design, Data, and Biostatistics Core). If funded, this project will assist Dr. Flood’s career goal of developing expertise to conduct independent aging research.
 
3. Project Title: Metabolic reprogramming by chaperone-mediated autophagy downstream of the lifespan-extending PTEN transgene
  Leader: Joseph Endicott, Ph.D.
  PESC Year 18 (7/1/22-6/30/23) Maintaining the balance between glycolysis and oxidative phosphorylation is essential for disease-free aging. Oxidative capacity declines with age across diverse animal models, and compensatory increases in glycolysis have been hypothesized to contribute to a “Warburg transition” which makes aging mammals more susceptible to cancer. Global overexpression (OE) in mice of PTEN, an antagonist of the INS/PI3K/AKT pathway, shifts metabolism to favor oxidative phosphorylation over glycolysis and extends lifespan of male and female mice. Our unpublished work has found: (1) PTEN OE enhances chaperone-mediated autophagy (CMA); (2) In a CMA-dependent manner, PTEN negatively regulates proteins involved in glycolysis (PKLR and TKFC), and proteins that drain mitochondria of TCA cycle metabolites aketoglutarate and citrate to generate cytoplasmic acetyl-coA (IDH1 and ACLY); (3) a decrease in the hepatic abundance of these acetyl-coA and glycolysis enzymes is common to several longlived mouse models. These data suggest the hypothesis that enhanced CMA, downstream of PTEN, promotes a shift in energy production to favor oxidative phosphorylation over glycolysis by selective degradation of ACLY, IDH1, PKLR and TKFC. This hypothesis will be evaluated in two Specific Aims: (1) Characterize the mechanism through which CMA regulates the balance between glycolysis and oxidative phosphorylation, downstream of PTEN, and (2) Evaluate lysosomal targeting of glycolysis and cytoplasmic acetyl-coA enzymes in PTEN OE and PTEN KO mice. We anticipate that successful completion of this project will demonstrate an important mechanistic link between CMA and the longevity promoting PTEN transgene, providing a strong justification for future grant applications developing CMA-enhancing drugs for modulating aging.
 
4. Project Title: Intersection of Insomnia and Centralized Pain in Older Adults: Effects on Medication Use
  Leader: Michael Smith, Pharm.D.
  PESC Year 18 (7/1/22-6/30/23) Insomnia and centralized pain are common and difficult to manage in older adults. Medications used to treat these conditions are included in the American Geriatrics Society Beers Criteria® for Potentially Inappropriate Medication (PIM) Use in Older Adults. Use of PIMs for these conditions is associated with poor outcomes, including increased risk of mortality. Our central hypothesis is that centralized pain in older adults with insomnia will confer a greater PIM burden than insomnia alone. Since both chronic pain and insomnia individually are associated with increased PIM use, it is likely that co-occurrence of these conditions would be associated with greater likelihood of PIM use. The primary objective of this pilot study is to understand medication use in the context of how increasing age mediates the interaction between insomnia and centralized pain. This will be achieved through the following Specific Aims: Aim 1: Determine the effect of age on rates of centralized pain in older adults with insomnia. H1: Increasing age will be associated with greater likelihood of centralized pain in older adults with insomnia. This quantitative aim will utilize a newly validated method (Schrepf et al. 2020) to quantify the proportion of older adults ? 55 years of age, stratified by age group, with insomnia who have co-occurring centralized pain using University of Michigan Health System Electronic Health Record (EHR) data. Aim 2: Quantify the effect of centralized pain on PIM use in older adults with insomnia. H2: Older adults with both centralized pain and insomnia will have greater PIM burden, quantified using the Drug Burden Index (DBI), than those with insomnia alone. This quantitative aim will advance the previous method using centralized pain diagnosis codes combined with a validated measure to determine the burden of anticholinergic and sedative use in older adults with insomnia and centralized pain. This study will provide a targeted population and baseline medication risk description for future intervention studies.
 
5. Project Title: Cross-national comparisons of disability among older adults with diabetes in 23 countries
  Leader: Shen Dewar, M.D.
  PESC Year 18 (7/1/22-6/30/23) Obesity is a growing health problem and current models of obesity care are limited in older adults. Despite the unique health care needs of older adults with obesity, currently there is no evidence-based model for this age group to manage obesity and associated disability (such as in mobility), symptoms (such as pain), multiple health issues due to long term effects of obesity (such as heart failure), and care complexity related to social determinants of health. As proof of concept, PI Dewar developed the Optimal Health, Weight, and Lifestyle (OHWL) clinic to optimize treatment of comorbid health conditions, physical function and diet in older adults with obesity. Only 1/3 of the 44 initial participants were adherent to medical specialist and therapist referrals. The remaining patients faced challenges such as lack of support for adherence to lifestyle change, low self-efficacy, and poor linkage to community resources. To address these barriers, a more comprehensive OHWL Program is proposed that features three primary components: 1) an OHWL Care Provider (oriented to obesity-centered older adult care); 2) an OHWL care manager (to assess and guide the custom intervention); and 3) a social worker to provide linkage to community resources as well as caregiver support/education. The goal of this PESC pilot is to test the feasibility and preliminary outcomes of this new model of care for older adults with obesity. In older adults (n=40, aged ?60) with obesity (BMI?35), and at least 2 obesity related comorbidities, aims in this PESC pilot are to: 1) Evaluate extent of changes in key quantitative outcomes (such as mobility and pain); and 2) Conduct a mixed methods process evaluation, guided by the RE-AIM model, of program feasibility, barriers and facilitators. The goal of the OHWL Program is to promote a patient-centered model of care to improve the functioning and quality of life of older adults with obesity, especially those from vulnerable populations who face barriers to lifestyle change. These pilot data will inform the creation of materials for a larger NIA-funded trial to be led by PI Dewar and mentors Alexander and Janevic as MPIs, to demonstrate scalability, efficacy, and costeffectiveness of this new model.
 
6. Project Title: Establishment of aged microbiota in germ free mice
  Leader: Vincent Young, M.D., Ph.D.
  LAC Year 17 (7/1/21-6/30/23) *RAPID PILOT* The normal microbe populations of the gut contribute to fostering immune system maturation, digestion assistance, and protection against pathogen invasion. Many age-associated conditions such as cardiovascular disease, cancer, and diabetes have been associated with abnormal host-microbe interactions. Elderly individuals are also moresusceptible to Clostridiodes difficile with an increased risk of developing disease- related complications. We are specifically interested in understanding how age-relatedchanges in the microbiota affect the outcomes of infection with Clostridioides difficile.
 
7. Project Title: Inflammation and the risk for cognitive decline and dementia after COVID-19
  Leader: Natalie Tronson, Ph.D.
  PESC Year 17 (7/1/21-6/30/22) Illness and stress are common risk factors for age-related cognitive decline, Alzheimer's Disease, and other dementias, likely via activation of neuroimmune inflammatory pathways in the brain. This has been difficult to study, however, because altered neuroinflammation is also a consequence of aging and of neurodegeneration. We have recently developed a mouse model within which to study the persistent consequences of immune challenge on memory, and in this project propose to apply this model to understand how transient illness during midlife increases risk for later, age-related cognitive decline, memory impairments, and dementia. Here, we will develop modified protocols to specifically examine COVID-19-like inflammatory pathways on memory across adulthood. COVID-19 is of particular relevance for cognitive decline and dementias because, unlike other illnesses including influenza, many patients experience a post-acute COVID-19 syndrome that includes memory impairments and "brain fog". Given the immense number of people affected by COVID-19, the pandemic is likely to dramatically increase the number of people impacted by age-related cognitive decline and dementias in the years to come. Here, we will determine whether and how single-stranded RNA (ssRNA)-viral mimic triggered inflammation accelerates aging-related cognitive decline in males and females long after resolution of illness.
 
8. Project Title: The gut microbiome as a mediator of age-related changes in fever response in sepsis
  Leader: Rishi Chanderraj
  Aging results in a blunted fever response in sepsis, which predicts adverse clinical outcomes. Fever response is a readily-measured index of systemic inflammation and metabolism. I have recently shown that gut microbiota (specifically Lachnospiraceae, a prominent producer of systemically-active metabolites), influences temperature response in humans and animal models. I have also shown that anti-anaerobic antibiotics 1) cause greater microbiome disruption than other antibiotics and 2) increase patient risk of mortality. The central hypothesis of this proposal is that age-related changes in the immune response and metabolic response in sepsis are mediated by gut microbiota. The specific objectives of the study are to: 1) determine how aging modulates the relationship between gut microbiota and fever response and 2) determine how gut anaerobe depletion modulates temperature response in geriatric patients with sepsis.
 
9. Project Title: Visuomotor Integration as a Predictor of Mobility and Fall Risk in Autistic Older Adults
  Leader: Haylie Miller
  Our study objective is to quantify effects of visuomotor integration on postural control, falls, and mobility in autistic vs. neurotypical older adults, accounting for cognitive, sensory, and physical capacities. To do this, we will use our computer vision algorithm to analyze multimodal visuomotor data during experimental tasks with varying demands. We have separate sets of preliminary data showing that autistic children, adolescents, and young adults have unstable postural control and eye movement, a high rate of falls, and functional mobility problems, but there are knowledge gaps in the relationship between these domains and their presentation in older adulthood. Our central hypothesis, informed by these data, is that cognitive skills mediate the relationship between the autistic phenotype of sensory/physical capacities and falls/mobility problems.
 
10. Project Title: Exploring the Relationship between the Social Determinants of Health and Systemic Markers of Mitochondrial Bioenergetics Among Older Adults
  Leader: Kate Duchowny
  The social determinants of health (SDOH), defined as the conditions by which people are born, grow, live work and age, are strongly associated with individual and population health outcomes across the life course. Despite the critical role the SDOH play in shaping health and well-being, the specific mechanisms by which social factors influence biologic properties of aging remains poorly understood. Recent work on mitochondrial function offers promise as a cellular mechanism by which the social determinants become biologically embedded and may therefore be implicated in long-standing inequities in aging-related decline and disease. However, to date, our understanding of mitochondrial function as a key biologic mechanism to aging has been hampered by methodological challenges. This proposal addresses these obstacles by leveraging blood-based markers of mitochondrial bioenergetics via the respirometry in frozen samples (RIFS) method while also linking these measures to the SDOH. Our approach offers a unique opportunity to harness cost-effective and minimally invasive techniques from frozen blood while laying the groundwork for larger-scale, population health studies. Our overall objective is to examine whether novel systemic markers of mitochondrial bioenergetics derived from frozen blood samples are associated with chronologic age and key social determinants of health.
 
11. Project Title: Detection and Prediction of Mild Cognitive Impairment in Seniors with Memory Complaints
  Leader: Tongtong Li
  Developing economically viable assessment tools and biomarkers that are highly sensitive to cognitive decline and neural dysfunction, before frank Alzheimer’s disease (AD) pathology, is critical for the study of neurodegenerative mechanisms and interventions to promote cognitive resiliency. In this interdisciplinary research, taking the brain as a communication network, our goal is to develop a cost effective, highly sensitive and reliable tool for early detection of people at risk for mild cognitive impairment (MCI), based on EEG data and neuropsychological assessments and by exploiting advanced techniques in communication networking, information theory and artificial intelligence.
 
12. Project Title: Assessing CT-based Biomarkers of Cardiovascular Disease in Older Adults
  Leader: Steven Horbal
  Cardiovascular disease is attributed to 1 in 4 deaths United States. Among theses deaths, 50% have no prior clinical symptoms or diagnosis. Most major cardiovascular events, even in older individuals, are preventable through the early identification and mitigation of modifiable risk factors. The fundamental tenet of primary prevention is that treatment decisions are carefully matched by accurate risk assessments. Biomarkers obtained from medical imaging can provide detailed body composition information that may improve cardiovascular risk prediction models. Among other biomarkers and methodologies, aortic calcification is an emerging clinical correlate that shows strong promise in preventative surveillance of clinical populations. Aortic calcification can be extracted from abdominal computed tomography scans, contextualized among population-level cohorts, and added to cardiovascular risk prediction models. Further investigation of clinically relevant populations is necessary to strengthen the internal and external validity of aortic calcification and other biomarkers of aging. This study will develop a cohort of 8000+ participants with abdominal CT-scans and are over the age of 65.
 
DEVELOPMENT PROJECTS (2 Development Projects Listed)
1. Project Title: Software tools for extracting data from HRS database
  Leader: Andrzej Galecki; Julie Bynum
  Core(s): Design, Data, and Biostatistics Core (DDBC)
  Core Development Project is designed to develop and maintain a library of SAS macros and functions that can be used by researchers to derive commonly used variables in Health Retirement Study. The goal is developing streamlined SAS codes using SAS Function Compiler (FCMP) procedure that could be used by researchers to extract data directly from the HRS raw datasets. Tools developed for this project have a potential to be implemented in international HRS-like dataset, including data from US, England, SHARE (European Countries), China, Mexico, South Korea, Japan, and South Africa.
 
2. Project Title: Develop a real time sensor to detect hyponatremia
  Leader: James Ashton-Miller
  Core(s): Biomechanics Core (BC)
 

Develop a real time sensor to detect hyponatremia
 
RESEARCH (0 Projects Listed)
PUBLICATIONS
2024
 
2023
  1. Incidence and risk factors for bacterial infection using bortezomib, lenalidomide, and dexamethasone (RVd) in newly diagnosed multiple myeloma.
    Bici A, Pianko MJ, Nachar VR
    Leuk Lymphoma, 2023 Feb, 64(2): 407-414
    https://doi.org/10.1080/10428194.2022.2138380 | PMID: 36308285 | PMCID: PMC9993956
    Citations: NA | AltScore: 4.35
  2. Influence of mild cognitive impairment on patient and care partner decision-making for acute ischemic stroke.
    Blair EM, Reale BK, Zahuranec DB, Forman J, Langa KM, Giordani BJ, Plassman BL, Welsh-Bohmer KA, Wang J, Kollman CD, Levine DA
    J Stroke Cerebrovasc Dis, 2023 Jun, 32(6): 107068
    https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107068 | PMID: 37004301 | PMCID: PMC10499500
    Citations: NA | AltScore: 1.5
  3. Multimorbidity and Functional Disability among Older Adults: The Role of Inflammation and Glycemic Status - An Observational Longitudinal Study.
    Botoseneanu A, Markwardt S, Qui?ones AR
    Gerontology, 2023, 69(7): 826-838
    https://doi.org/10.1159/000528648 | PMID: 36858034 | PMCID: PMC10442862
    Citations: NA | AltScore: 0.5
  4. A cultural neuropsychological approach to harmonization of cognitive data across culturally and linguistically diverse older adult populations.
    Brice?o EM, Arce Renter?a M, Gross AL, Jones RN, Gonzalez C, Wong R, Weir DR, Langa KM, Manly JJ
    Neuropsychology, 2023 Mar, 37(3): 247-257
    https://doi.org/10.1037/neu0000816 | PMID: 35482625 | PMCID: PMC9639608
    Citations: 4 | AltScore: 12.35
  5. Cognitive recovery trajectories 3 months following stroke in Mexican American and non-Hispanic white adults.
    Brice?o EM, Dong L, Levine DA, Kwicklis M, Lisabeth LD, Morgenstern LB
    J Stroke Cerebrovasc Dis, 2023 Feb, 32(2): 106902
    https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106902 | PMID: 36459957 | PMCID: PMC10249629
    Citations: NA | AltScore: 7
  6. Nursing Home to Nursing Home Transfers during the Early COVID-19 Pandemic.
    Chang CH, Park P, Bynum JP, Montoya A
    J Am Med Dir Assoc, 2023 Apr, 24(4): 441-446
    https://doi.org/10.1016/j.jamda.2023.01.028 | PMID: 36878263 | PMCID: PMC9915045
    Citations: NA | AltScore: 10
  7. Novel methodology for detection and prediction of mild cognitive impairment using resting-state EEG.
    Deng J, Sun B, Kavcic V, Liu M, Giordani B, Li T
    Alzheimers Dement, 2023 Jul 26
    https://doi.org/10.1002/alz.13411 | PMID: 37496373
    Citations: NA | AltScore: 7
  8. A comparison of MRI-based pelvic floor support measures between young and old women with prolapse.
    Duarte Thibault M, Chen L, Huebner M, DeLancey JO, Swenson CW
    Int Urogynecol J, 2023 Sep, 34(9): 2081-2088
    https://doi.org/10.1007/s00192-023-05505-5 | PMID: 36971829 | PMCID: PMC10566251
    Citations: NA | AltScore: NA
  9. Michigan men's diabetes project II: Protocol for peer-led diabetes self-management education and long-term support in Black men.
    Hawkins J, Sengupta S, Kloss K, Kurnick K, Ewen A, Nwawkwo R, Funnell M, Mitchell J, Jones L, Piatt G
    PLoS One, 2023, 18(3): e0277733
    https://doi.org/10.1371/journal.pone.0277733 | PMID: 36862648 | PMCID: PMC9980828
    Citations: 1 | AltScore: NA
  10. Association Between Acute Myocardial Infarction and Cognition.
    Johansen MC, Ye W, Gross A, Gottesman RF, Han D, Whitney R, Brice?o EM, Giordani BJ, Shore S, Elkind MSV, Manly JJ, Sacco RL, Fohner A, Griswold M, Psaty BM, Sidney S, Sussman J, Yaffe K, Moran AE, Heckbert S, Hughes TM, Galecki A, Levine DA
    JAMA Neurol, 2023 Jul 1, 80(7): 723-731
    https://doi.org/10.1001/jamaneurol.2023.1331 | PMID: 37252710 | PMCID: PMC10230369
    Citations: 4 | AltScore: 1110.91
  11. Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress.
    Kroll RG, Powell C, Chen J, Snider NT, St Hilaire C, Reddy A, Kim J, Pinsky DJ, Murthy VL, Sutton NR
    J Am Heart Assoc, 2023 May 2, 12(9): e027920
    https://doi.org/10.1161/JAHA.122.027920 | PMID: 37119076 | PMCID: PMC10227209
    Citations: NA | AltScore: 5.45
  12. Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors.
    Levine DA, Chen B, Galecki AT, Gross AL, Brice?o EM, Whitney RT, Ploutz-Snyder RJ, Giordani BJ, Sussman JB, Burke JF, Lazar RM, Howard VJ, Aparicio HJ, Beiser AS, Elkind MSV, Gottesman RF, Koton S, Pendlebury ST, Sharma A, Springer MV, Seshadri S, Romero JR, Hayward RA
    JAMA Netw Open, 2023 May 1, 6(5): e2313879
    https://doi.org/10.1001/jamanetworkopen.2023.13879 | PMID: 37195662 | PMCID: PMC10193182
    Citations: NA | AltScore: 402.78
  13. Patient Cognitive Status and Physician Recommendations for Cardiovascular Disease Treatment: Results of Two Nationwide, Randomized Survey Studies.
    Levine DA, Whitney RT, Galecki AT, Fagerlin A, Wallner LP, Shore S, Langa KM, Nallamothu BK, Morgenstern LB, Giordani B, Reale BK, Blair EM, Sharma A, Kabeto MU, Plassman BL, Zahuranec DB
    J Gen Intern Med, 2023 Aug 24
    https://doi.org/10.1007/s11606-023-08295-0 | PMID: 37620721
    Citations: NA | AltScore: NA
  14. Recapitulation of anti-aging phenotypes by global, but not by muscle-specific, deletion of PAPP-A in mice.
    Li X, Hager M, McPherson M, Lee M, Hagalwadi R, Skinner ME, Lombard D, Miller RA
    Geroscience, 2023 Apr, 45(2): 931-948
    https://doi.org/10.1007/s11357-022-00692-3 | PMID: 36542300 | PMCID: PMC9886707
    Citations: 4 | AltScore: 2.6
  15. Driving predictors in a cohort of cognitively impaired Mexican American and non-Hispanic White individuals.
    Malvitz M, Zahuranec DB, Chang W, Heeringa SG, Brice?o EM, Mehdipanah R, Gonzales XF, Levine DA, Langa KM, Garcia N, Morgenstern LB
    J Am Geriatr Soc, 2023 Jun 29
    https://doi.org/10.1111/jgs.18493 | PMID: 37382492
    Citations: NA | AltScore: NA
  16. Aging Rate Indicators: Speedometers for Aging Research in Mice.
    Miller RA, Li X, Garcia G
    Aging Biol, 2023, 1(1):
    https://doi.org/10.59368/agingbio.20230003 | PMID: 37694163 | PMCID: PMC10486275
    Citations: 1 | AltScore: NA
  17. When even two is a crowd: shared nursing home rooms and the risk of respiratory infection outbreaks.
    Mills JP, Mody L
    Lancet Healthy Longev, 2023 Mar, 4(3): e92-e93
    https://doi.org/10.1016/S2666-7568(23)00025-9 | PMID: 36870339 | PMCID: PMC9977301
    Citations: NA | AltScore: NA
  18. Cancer Treatment Patterns and Factors Affecting Receipt of Treatment in Older Adults: Results from the ASPREE Cancer Treatment Substudy (ACTS).
    Muhandiramge J, Warner ET, Zalcberg JR, Haydon A, Polekhina G, van Londen GJ, Gibbs P, Bernstein WB, Tie J, Millar JL, Mar VJ, McNeil JJ, Woods RL, Orchard SG, ASPREE Investigator Group
    Cancers (Basel), 2023 Feb 5, 15(4):
    https://doi.org/10.3390/cancers15041017 | PMID: 36831362 | PMCID: PMC9953887
    Citations: NA | AltScore: NA
  19. Electrochemical Sensing of Urinary Chloride Ion Concentration for Near Real-Time Monitoring.
    Nelson AM, Habibi S, DeLancey JOL, Ashton-Miller JA, Burns MA
    Biosensors (Basel), 2023 Feb 28, 13(3):
    https://doi.org/10.3390/bios13030331 | PMID: 36979543 | PMCID: PMC10046868
    Citations: NA | AltScore: NA
  20. Incorporating social environment data in infectious disease research.
    Noppert GA, Kubale JT
    Lancet Public Health, 2023 Feb, 8(2): e88-e89
    https://doi.org/10.1016/S2468-2667(23)00005-1 | PMID: 36669513 | PMCID: PMC10034715
    Citations: 1 | AltScore: 18.8
  21. Socioeconomic and race/ethnic differences in immunosenescence: Evidence from the Health and Retirement Study.
    Noppert GA, Stebbins RC, Dowd JB, Aiello AE
    Brain Behav Immun, 2023 Jan, 107: 361-368
    https://doi.org/10.1016/j.bbi.2022.10.019 | PMID: 36347419 | PMCID: PMC9636606
    Citations: 5 | AltScore: 7.3
  22. Association of Obesity With Cognitive Decline in Black and White Americans.
    Quaye E, Galecki AT, Tilton N, Whitney R, Brice?o EM, Elkind MSV, Fitzpatrick AL, Gottesman RF, Griswold M, Gross AL, Heckbert SR, Hughes TM, Longstreth WT Jr, Sacco RL, Sidney S, Windham BG, Yaffe K, Levine DA
    Neurology, 2023 Jan 10, 100(2): e220-e231
    https://doi.org/10.1212/WNL.0000000000201367 | PMID: 36257719 | PMCID: PMC9841449
    Citations: 1 | AltScore: 35
  23. Electronic health record enhancements that increased capture of home blood pressures among geriatric patients during pandemic-era virtual visits.
    Russell AE, Khosrodad N, Clark S, Min L
    J Am Geriatr Soc, 2023 May, 71(5): 1660-1662
    https://doi.org/10.1111/jgs.18205 | PMID: 36602155 | PMCID: PMC10175093
    Citations: NA | AltScore: 1.25
  24. Does computerized cognitive training improve diabetes self-management and cognition? A randomized control trial of middle-aged and older veterans with type 2 diabetes.
    Silverman JM, Zhu CW, Schmeidler J, Lee PG, Alexander NB, Guerrero-Berroa E, Beeri MS, West RK, Sano M, Nabozny M, Karran M
    Diabetes Res Clin Pract, 2023 Jan, 195: 110149
    https://doi.org/10.1016/j.diabres.2022.110149 | PMID: 36427629 | PMCID: PMC9908839
    Citations: 1 | AltScore: 0.5
  25. Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification.
    Sutton NR, Malhotra R, St Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y
    Arterioscler Thromb Vasc Biol, 2023 Jan, 43(1): 15-29
    https://doi.org/10.1161/ATVBAHA.122.317332 | PMID: 36412195 | PMCID: PMC9793888
    Citations: 6 | AltScore: 14.4
  26. Engaging diverse populations in aging research during the COVID-19 pandemic: Lessons learned from four National Institutes of Health funded-Centers.
    Vega IE, Ajrouch KJ, Rorai V, Gadwa R, Roberts JS, Nyquist L
    Front Public Health, 2023, 11: 1062385
    https://doi.org/10.3389/fpubh.2023.1062385 | PMID: 37081958 | PMCID: PMC10110869
    Citations: NA | AltScore: 1.75
  27. Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement.
    Vivaldo CA, Lee J, Shorkey M, Keerthy A, Rothschild G
    PLoS Biol, 2023 Aug, 21(8): e3002277
    https://doi.org/10.1371/journal.pbio.3002277 | PMID: 37651461 | PMCID: PMC10499203
    Citations: NA | AltScore: NA
  28. Predictors and Interrelationship of Patient-Reported Outcomes in Antiphospholipid Syndrome: A Cross-Sectional Study.
    Weiner JK, Smith T, Hoy CK, Sarosh C, Madison JA, Ambati A, Tambralli A, Peters N, Packel C, Gockman K, Zuo Y, Brice?o EM, Nagaraja V, Knight JS
    ACR Open Rheumatol, 2023 Jan, 5(1): 28-37
    https://doi.org/10.1002/acr2.11512 | PMID: 36461647 | PMCID: PMC9837395
    Citations: NA | AltScore: 91.5
  29. Meaning-centered pain coping skills training for patients with metastatic cancer: Results of a randomized controlled pilot trial.
    Winger JG, Kelleher SA, Ramos K, Check DK, Yu JA, Powell VD, Lerebours R, Olsen MK, Keefe FJ, Steinhauser KE, Porter LS, Breitbart WS, Somers TJ
    Psychooncology, 2023 May 12, 32(7): 1096-1105
    https://doi.org/10.1002/pon.6151 | PMID: 37173865 | PMCID: PMC10330450
    Citations: NA | AltScore: 5.75
  30. Three-dimensional chromatin re-organization during muscle stem cell aging.
    Yang BA, Larouche JA, Sabin KM, Fraczek PM, Parker SCJ, Aguilar CA
    Aging Cell, 2023 Apr, 22(4): e13789
    https://doi.org/10.1111/acel.13789 | PMID: 36727578 | PMCID: PMC10086523
    Citations: 2 | AltScore: 13.6
  31. Aspirin for Secondary Prevention of Cardiovascular Disease in 51 Low-, Middle-, and High-Income Countries.
    Yoo SGK, Chung GS, Bahendeka SK, Sibai AM, Damasceno A, Farzadfar F, Rohloff P, Houehanou C, Norov B, Karki KB, Azangou-Khyavy M, Marcus ME, Aryal KK, Brant LCC, Theilmann M, C?fkov? R, Lunet N, Gurung MS, Mwangi JK, Martins J, Haghshenas R, Sturua L, Vollmer S, B?rnighausen T, Atun R, Sussman JB, Singh K, Saeedi Moghaddam S, Guwatudde D, Geldsetzer P, Manne-Goehler J, Huffman MD, Davies JI, Flood D
    JAMA, 2023 Aug 22, 330(8): 715-724
    https://doi.org/10.1001/jama.2023.12905 | PMID: 37606674 | PMCID: PMC10445202
    Citations: NA | AltScore: 438.88
  32. Neighborhood 'Disamenities': local barriers and cognitive function among Black and white aging adults.
    Yu W, Esposito M, Li M, Clarke P, Judd S, Finlay J
    BMC Public Health, 2023 Jan 30, 23(1): 197
    https://doi.org/10.1186/s12889-023-15026-x | PMID: 36717795 | PMCID: PMC9885664
    Citations: 1 | AltScore: 10.5
  33. PTEN is both an activator and a substrate of chaperone-mediated autophagy.
    Zhang KK, Burns CM, Skinner ME, Lombard DB, Miller RA, Endicott SJ
    J Cell Biol, 2023 Sep 4, 222(9):
    https://doi.org/10.1083/jcb.202208150 | PMID: 37418003 | PMCID: PMC10327811
    Citations: NA | AltScore: NA
  34. LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice.
    Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA, Endicott SJ
    Aging (Albany NY), 2023 Jun 13, 15(11): 4685-4698
    https://doi.org/10.18632/aging.204796 | PMID: 37315291 | PMCID: PMC10292871
    Citations: NA | AltScore: 4.1


EXTERNAL ADVISORY BOARD MEMBERS

Kenneth Schmader
Duke University
Serving since 2017 (7 years)

George Kuchel
University of Connecticut Health Center
Serving since 2023 (1 years)

Karen Bandeen-Roche
Johns Hopkins University
Serving since 2023 (1 years)

RECOGNITION AND AWARDS (2023-2024)

Recognition and Awards not specified.

MINORITY RESEARCH

General Brief Description of Minority Activities:

University of Michigan

Claude D. Pepper Older Americans Independence Center

 

 

Minority Research:  List activities with minority trainees and research focusing on hypotheses dealing with minority health. Clinical research that has an expected number of minority subjects (a NIH requirement) is NOT what is desired for this section. Only work that has a comparison of minority members to majority members such as work on health disparities should be included. 

 

Minority Trainee(s):


Emily Briceño-Abreau, PhD, Assistant Professor, Physical Medicine and Rehabilitation, is supported by the REC. Her research focus is on the measurement of cognition across language and education among Mexican American and non-Hispanic white older adults.

 

Jaclynn Hawkins, MSW, PhD, supported by PESC and REC in 2019-2020, was promoted to Associate Professor with Tenure, School of Social Work in 2022. She also was appointed as the new Associate Director of the Vivian A. and James L. Curtis Center for Health Equity Research and Training in 2021. Her research supported by the OAIC focuses on Type 2 diabetes self-management in older African American men.

 

Trainees Focusing on Minority Health Issues.

 

Emily Briceño-Abreau, Ph.D.

 

Research Articles:

 

Becker CJ, Heeringa SG, Chang W, Briceño EM, Mehdipanah R, Levine DA, Langa KM, Gonzales XF, Garcia N, Longoria R, Springer MV, Zahuranec DB, Morgenstern LB. Differential Impact of Stroke on Cognitive Impairment in Mexican Americans and Non-Hispanic White Americans. Stroke. 2022 Nov;53(11):3394-3400. doi: 10.1161/STROKEAHA.122.039533. Epub 2022 Aug 12. PMID: 35959679; PMCID: PMC9613525.

Briceño EM, Arce Rentería M, Gross AL, Jones RN, Gonzalez C, Wong R, Weir DR, Langa KM, Manly JJ. A cultural neuropsychological approach to harmonization of cognitive data across culturally and linguistically diverse older adult populations. Neuropsychology. 2022 Apr 28:10.1037/neu0000816. doi: 10.1037/neu0000816. Epub ahead of print. PMID: 35482625; PMCID: PMC9639608.

Briceño EM, Dong L, Levine DA, Kwicklis M, Lisabeth LD, Morgenstern LB. Cognitive recovery trajectories 3 months following stroke in Mexican American and non-Hispanic white adults. J Stroke Cerebrovasc Dis. 2023 Feb;32(2):106902. doi: 10.1016/j.jstrokecerebrovasdis.2022.106902. Epub 2022 Nov 29. PMID: 36459957; PMCID: PMC10249629.

Briceño EM, Mehdipanah R, Gonzales XF, Heeringa SG, Levine DA, Langa KM, Zahs D, Garcia N, Longoria R, Vargas A, Morgenstern LB. Differential Relationships Between the Montreal Cognitive Assessment and Informant-Rated Cognitive Decline Among Mexican Americans and Non-Hispanic Whites. J Geriatr Psychiatry Neurol. 2021 Jul 22:8919887211029383. doi: 10.1177/08919887211029383. Epub ahead of print. PMID: 34291678; PMCID: PMC8782915.

Briceño EM, Mehdipanah R, Gonzales XF, Heeringa SG, Levine DA, Langa KM, Zahs D, Garcia N, Longoria R, Morgenstern LB. Bilingualism, assessment language, and the Montreal Cognitive Assessment in Mexican Americans. J Am Geriatr Soc. 2021 Jul;69(7):1971-1981. doi: 10.1111/jgs.17209. Epub 2021 May 7. PMID: 33963535; PMCID: PMC8273138.

Davis MA, Lee KA, Harris M, Ha J, Langa KM, Bynum JPW, Hoffman GJ. Time to dementia diagnosis by race: A retrospective cohort study. J Am Geriatr Soc. 2022 Nov;70(11):3250-3259. doi: 10.1111/jgs.18078. Epub 2022 Oct 6. PMID: 36200557; PMCID: PMC9669160.

Dong L, Williams LS, Briceno E, Morgenstern LB, Lisabeth LD. Longitudinal assessment of depression during the first year after stroke: Dimensionality and measurement invariance. J Psychosom Res. 2022 Feb;153:110689. doi: 10.1016/j.jpsychores.2021.110689. Epub 2021 Dec 2. PMID: 34996018; PMCID: PMC9085722.

Gonzales XF, Heeringa SG, Briceño EM, Mehdipanah R, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB. Mexican Americans Participate in Research More than Expected while non-Hispanic Whites Participate Less than Expected. J Health Care Poor Underserved. 2022;33(2):590-596. doi: 10.1353/hpu.2022.0049. PMID: 35574862; PMCID: PMC9132253.

Hawkins J, Gilcher K, Schwenzer C, Lutz M. Investigating Racial Differences among Men in COVID-19 Diagnosis, and Related Psychosocial and Behavioral Factors: Data from the Michigan Men's Health Event. Int J Environ Res Public Health. 2021 Mar 22;18(6):3284. doi: 10.3390/ijerph18063284. PMID: 33810055; PMCID: PMC8005096.

Hawkins J, Kieffer EC, Sinco B, Piatt G, Jones L, Mitchell J, Espitia N, LeBron A, Kloss KA, Kurnick K, Palmsiano G, Spencer MS. Using Path Analysis and Linear Regression to Test for Gender and Participation: Effects in a Culturally Tailored Diabetes Intervention for Latino Adults. Int J Environ Res Public Health. 2022 Sep 22;19(19):11982. doi: 10.3390/ijerph191911982. PMID: 36231282; PMCID: PMC9565909.

Hawkins J, Kloss K, Funnell M, Nwankwo R, Schwenzer C, Smith F, Piatt G. Michigan Men's diabetes project (MenD): protocol for a peer leader diabetes self-management education and support intervention. BMC Public Health. 2021 Mar 22;21(1):562. doi: 10.1186/s12889-021-10613-2. PMID: 33752609; PMCID: PMC7983198.

Hawkins J, Sengupta S, Kloss K, Kurnick K, Ewen A, Nwawkwo R, Funnell M, Mitchell J, Jones L, Piatt G. Michigan men's diabetes project II: Protocol for peer-led diabetes self-management education and long-term support in Black men. PLoS One. 2023 Mar 2;18(3):e0277733. doi: 10.1371/journal.pone.0277733. PMID: 36862648; PMCID: PMC9980828.

Janevic M, Robinson-Lane SG, Courser R, Brines E, Hassett AL. A Community Health Worker-Led Positive Psychology Intervention for African American Older Adults With Chronic Pain. Gerontologist. 2022 Oct 19;62(9):1369-1380. doi: 10.1093/geront/gnac010. PMID: 35394525; PMCID: PMC9579460.

Janevic M, Robinson-Lane SG, Murphy SL, Courser R, Piette JD. A Pilot Study of a Chronic Pain Self-Management Program Delivered by Community Health Workers to Underserved African American Older Adults. Pain Med. 2022 Dec 1;23(12):1965-1978. doi: 10.1093/pm/pnaa468. PMID: 33779759; PMCID: PMC9714529.

Johansen MC, Ye W, Gross A, Gottesman RF, Han D, Whitney R, Briceño EM, Giordani BJ, Shore S, Elkind MSV, Manly JJ, Sacco RL, Fohner A, Griswold M, Psaty BM, Sidney S, Sussman J, Yaffe K, Moran AE, Heckbert S, Hughes TM, Galecki A, Levine DA. Association Between Acute Myocardial Infarction and Cognition. JAMA Neurol. 2023 May 30:e231331. doi: 10.1001/jamaneurol.2023.1331. Epub ahead of print. PMID: 37252710; PMCID: PMC10230369.

Jones LM, Moss KO, Mitchell J, Still C, Hawkins J, Tang E, Wright KD. Challenges to dietary hypertension self-management as described by a sample of African American older adults. Worldviews Evid Based Nurs. 2022 Feb;19(1):64-72. doi: 10.1111/wvn.12555. Epub 2022 Jan 22. PMID: 35064763; PMCID: PMC9701083.

Khan N, Briceño EM, Mehdipanah R, Lewandowski-Romps L, Heeringa SG, Garcia N, Levine DA, Langa KM, Morgenstern LB. A community-based study of reporting demographic and clinical information concordance between informants and cognitively impaired participants. Aging Clin Exp Res. 2023 May 19. doi: 10.1007/s40520-023-02435-6. Epub ahead of print. PMID: 37204754.

Khan N, Garcia N, Mehdipanah R, Briceño EM, Heeringa SG, Levine DA, Gonzales XF, Langa KM, Longoria R, Morgenstern LB. Lack of Any Caregiving for Those with Dementia. J Alzheimers Dis. 2022;86(2):531-535. doi: 10.3233/JAD-215418. PMID: 35068465; PMCID: PMC8960337.

LeBrón AMW, Espitia NR, Kieffer EC, Sinco BR, Hawkins JM, Nicklett EJ, Palmisano G, Heisler M, Spencer MS. Using path analysis to model the process of change in HbA1c among African Americans and Latinos in a community health worker diabetes intervention. Patient Educ Couns. 2022 Jul;105(7):2166-2173. doi: 10.1016/j.pec.2021.11.025. Epub 2021 Nov 28. PMID: 34903389

Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman WH, Park SK. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental pollution (Barking, Essex : 1987). 2022 June 15;303:119164. PubMed PMID: 35306088; PubMed Central PMCID: PMC9883839; DOI:10.1016/j.envpol.2022.119164.

Leggett AN, Strominger J, Robinson-Lane SG, Maust DT. Disparities in Health Care Task Participation and Provider Communication by Family Caregiver Race. J Gen Intern Med. 2022 Apr;37(5):1321-1324. doi: 10.1007/s11606-021-06766-w. Epub 2021 Apr 8. PMID: 33830417; PMCID: PMC8971267.

Lenko R, Voepel-Lewis T, Robinson-Lane SG, Silveira MJ, Hoffman GJ. Racial and Ethnic Differences in Informal and Formal Advance Care Planning Among U.S. Older Adults. J Aging Health. 2022 Dec;34(9-10):1281-1290. doi: 10.1177/08982643221104926. Epub 2022 May 27. PMID: 35621163; PMCID: PMC9633341.

Levine DA, Chen B, Galecki AT, Gross AL, Briceño EM, Whitney RT, Ploutz-Snyder RJ, Giordani BJ, Sussman JB, Burke JF, Lazar RM, Howard VJ, Aparicio HJ, Beiser AS, Elkind MSV, Gottesman RF, Koton S, Pendlebury ST, Sharma A, Springer MV, Seshadri S, Romero JR, Hayward RA. Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors. JAMA Netw Open. 2023 May 1;6(5):e2313879. doi: 10.1001/jamanetworkopen.2023.13879. PMID: 37195662; PMCID: PMC10193182.

Levine DA, Gross AL, Briceño EM, Tilton N, Whitney R, Han D, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Elkind MSV, Moran AE, Tom S, Gottesman RF, Gaskin DJ, Sidney S, Yaffe K, Sacco RL, Heckbert SR, Hughes TM, Lopez OL, Allen NB, Galecki AT. Blood Pressure and Later-Life Cognition in Hispanic and White Adults (BP-COG): A Pooled Cohort Analysis of ARIC, CARDIA, CHS, FOS, MESA, and NOMAS. J Alzheimers Dis. 2022;89(3):1103-1117. doi: 10.3233/JAD-220366. Erratum in: J Alzheimers Dis. 2023;92(2):723. PMID: 35964190; PMCID: PMC10041434.

Markus HS, van Der Flier WM, Smith EE, Bath P, Biessels GJ, Briceno E, Brodtman A, Chabriat H, Chen C, de Leeuw FE, Egle M, Ganesh A, Georgakis MK, Gottesman RF, Kwon S, Launer L, Mok V, O'Brien J, Ottenhoff L, Pendlebury S, Richard E, Sachdev P, Schmidt R, Springer M, Tiedt S, Wardlaw JM, Verdelho A, Webb A, Werring D, Duering M, Levine D, Dichgans M. Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE): A Review. JAMA Neurol. 2022 Nov 1;79(11):1187-1198. doi: 10.1001/jamaneurol.2022.2262. PMID: 35969390.

Marshall C, Havis I, Herreshoff E, Lewis C, Kotagal V. Racial Differences in Trust and Risk Disclosure Preferences Among Older Registered Research Volunteers Screened for Prodromal Synucleinopathies. Gerontol Geriatr Med. 2022 May 18;8:23337214221094184. doi: 10.1177/23337214221094184. PMID: 35601119; PMCID: PMC9121461.

Mehdipanah R, Briceño EM, Gonzales XF, Heeringa SG, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB. Dementia care needs for individuals and caregivers among Mexican Americans and non-Hispanic Whites. Aging Ment Health. 2022 Aug;26(8):1630-1641. doi: 10.1080/13607863.2021.1925222. Epub 2021 Jun 7. PMID: 34096422; PMCID: PMC8864934.

Mehdipanah R, Briceño EM, Heeringa SG, Gonzales XF, Levine DA, Langa KM, Garcia N, Longoria R, Chang W, Morgenstern LB. Neighborhood SES and Cognitive Function Among Hispanic/Latinx Residents: Why Where You Live Matters. Am J Prev Med. 2022 Oct;63(4):574-581. doi: 10.1016/j.amepre.2022.04.016. Epub 2022 Jun 9. PMID: 35691843.

Noppert GA, Stebbins RC, Dowd JB, Aiello AE. Socioeconomic and race/ethnic differences in immunosenescence: Evidence from the Health and Retirement Study. Brain Behav Immun. 2023 Jan;107:361-368. doi: 10.1016/j.bbi.2022.10.019. Epub 2022 Nov 5. PMID: 36347419; PMCID: PMC9636606

Quaye E, Galecki AT, Tilton N, Whitney R, Briceño EM, Elkind MS V, Fitzpatrick AL, Gottesman RF, Griswold M, Gross AL, Heckbert SR, Hughes TM, Longstreth WT, Sacco RL, Sidney S, Windham BG, Yaffe K, Levine DA: Association of Obesity With Cognitive Decline in Black and White Americans. Neurology.100(2): e220-e231, 01/2023. PMCID: PMC9841449; DOI: 10.1212/WNL.0000000000201367

Robinson-Lane SG, Block L, Bowers BJ, Cacchione PZ, Gilmore-Bykovskyi A. The Intersections of Structural Racism and Ageism in the Time of COVID-19: A Call to Action for Gerontological Nursing Science. Res Gerontol Nurs. 2022 Jan-Feb;15(1):6-13. doi: 10.3928/19404921-20211209-03. Epub 2022 Jan 1. PMID: 35044863; PMCID: PMC8856583.

Robinson-Lane SG, Sutton NR, Chubb H, Yeow RY, Mazzara N, DeMarco K, Kim T, Chopra V. Race, Ethnicity, and 60-Day Outcomes After Hospitalization With COVID-19. J Am Med Dir Assoc. 2021 Nov;22(11):2245-2250. doi: 10.1016/j.jamda.2021.08.023. Epub 2021 Oct 5. PMID: 34716006; PMCID: PMC8490827.

Sutton NR, Robinson-Lane SG, Yeow RY, Chubb HA, Kim T, Chopra V. Racial and ethnic variation in COVID-19 care, treatment, and outcomes: A retrospective cohort study from the MiCOVID-19 registry. PLoS One. 2022 Nov 1;17(11):e0276806. doi: 10.1371/journal.pone.0276806. PMID: 36318576; PMCID: PMC9624408.

Vega IE, Ajrouch K, Rorai V, Gadwa R, Roberts JS, Nyquist L. Engaging diverse populations in aging research during the COVID-19 pandemic: Becoming a trusted resource. Front Public Health. 2023 in press. doi:10.3389/fpubh.2023.1062385

Weiner JK, Smith T, Hoy CK, Sarosh C, Madison JA, Ambati A, Tambralli A, Peters N, Packel C, Gockman K, Zuo Y, Briceño EM, Nagaraja V, Knight JS. Predictors and Interrelationship of Patient-Reported Outcomes in Antiphospholipid Syndrome: A Cross-Sectional Study. ACR Open Rheumatol. 2023 Jan;5(1):28-37. doi: 10.1002/acr2.11512. Epub 2022 Dec 2. PMID: 36461647; PMCID: PMC9837395.

Yu W, Esposito M, Li M, Clarke P, Judd S, Finlay J. Neighborhood 'Disamenities': local barriers and cognitive function among Black and white aging adults. BMC Public Health. 2023 Jan 30;23(1):197. doi: 10.1186/s12889-023-15026-x. PMID: 36717795; PMCID: PMC9885664.

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